The effect of the active substances of Saffromental capsule in improving depression symptoms


Conducted Researches

In a six-week study treatment in patients with major depressive disorder, one group received standardized saffron capsules three times a day and the other group received 100 mg/day imipramine capsules. Saffron capsules at this dose was found to be more effective than imipramine in the treatment of mild to moderate depression.5

In another similar study, saffron capsules were compared with fluoxetine. In this 6-week study, patients randomly received saffron capsule and fluoxetine capsule, 20 mg/ day. The findings of this study showed that saffron capsule at this dose was well comparable with fluoxetine in order to treat mild to moderate depression.6 

In another experiment, saffron capsules were studied as a satiety enhancer and thus led to weight loss. In this study, the effect of saffron capsules on improving mood, which decreased appetite and reduced snacking, were investigated. 60 mildly overweight women who participated in this study, randomly were given 1 saffron capsule or an inactive placebo. After 2 months, women who received saffron capsules reported both snacking reduction and weight loss comparing to the other group. In this study, it was suggested that the combination of an adequate diet with saffron supplementation might help subjects engaged in a weight loss program achieve their goal.7

In a randomized double-blind placebo-controlled study, 38 women with major depression and sexual dysfunction were stabilized on fluoxetine 40 mg/day for at least 6 weeks. Patients were randomly divided into two groups: group1) saffron 30 mg / day and group 2) placebo for 4 weeks. The Female Sexual Function Index was measured in the second and fourth weeks and side effects were systematically recorded. It has been indicated that saffron can effectively improve some of the fluoxetine-induced sexual problems.8



  1. Siddiqui, M. J. et al. Saffron (Crocus sativus L.): As an Antidepressant. J. Pharm. Bioallied Sci. 10, 173 (2018).
  2. Ramli, F. N., Sajak, A. A. B., Abas, F., Daud, Z. A. M. & Azlan, A. Effect of saffron extract and crocin in serum metabolites of induced obesity rats. Biomed Res. Int. 2020, (2020).
  3. Mashmoul, M., Azlan, A., Mohtarrudin, N., Yusof, B. N. M. & Khaza’ai, H. Saffron extract and crocin reduced biomarkers associated with obesity in rats fed a high-fat diet. Malays. J. Nutr. 23, 117–127 (2017).
  4. Kianbakht, S. & Hashem Dabaghian, F. Anti-obesity and anorectic effects of saffron and its constituent crocin in obese Wistar rat. J. Med. Plants 14, 25–33 (2015).
  5. Akhondzadeh, S. & Fallah-Pour, H. Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression: A pilot double-blind randomized trial. BMC Complement Altern Med 4, 12–17 (2004).
  6. Noorbala, A. A., Akhondzadeh, S., Tahmacebi-Pour, N. & Jamshidi, A. H. Hydro-alcoholic extract of Crocus sativus L. versus fluoxetine in the treatment of mild to moderate depression: A double-blind, randomized pilot trial. J. Ethnopharmacol. 97, 281–284 (2005).
  7. Gout, B., Bourges, C. & Paineau-Dubreuil, S. Satiereal, a Crocus sativus L extract, reduces snacking and increases satiety in a randomized placebo-controlled study of mildly overweight, healthy women. Nutr. Res. 30, 305–313 (2010).
  8. Ladan Kashani, Firoozeh Raisi, Sepideh Saroukhani, Hamid Sohrabi, Amirhossein Modabbernia, Abbas-Ali Nasehi, Amirhossein Jamshidi, Mandana Ashrafi, Parisa Mansouri, Padideh Ghaeli and Shahin Akhondzadeh. Saffron for treatment of fluoxetine-induced sexual dysfunction in women: randomized double-blind placebo-controlled study human psychopharmacology. Hum. Psychopharmacol Clin Exp, 28: 54–60 (2013).

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