30 Soft Gelatin Capsules

  • Migraine Syndromes Treatment
  • Reduces Migraine Frequency
  • Product name: Migracetum
  • Medicinal Form: Softgels
    Ingredients: Tanacetum parthenium L. extract standardized on minimum 0.24% parthenolide, PEG, Glycerol, Gelatin
  • Dosage and directions: Take one capsule daily, with a glass of water, preferably before a meal.
  • Prohibited Usage:
    • Not to be used by children under 2 years of age.
    • This product is contraindicated in cases of known allergy to plants of the Asteraceae family.
    • Avoid concomitant use of this product with nonsteroidal anti-inflammatory agent (NSAID) drugs.
    • All patients scheduled for surgery should refrain from taking this capsule
  • Use in Pregnancy and Lactation:Should not be used during pregnancy and lactation.
  • Side Effects:
    • Gastrointestinal problems may occur following product consumption.
    • Allergic reactions may occur following product consumption.
    • There is a possibility of allergic reactions after taking this capsule.
  • Cautions and warnings:
    • Do not chew
    • This product inhibits platelet aggregation, it should be used with caution in patients who take antiplatelet drugs such as aspirin, warfarin, and dipyridamole.
    • Reduce the dose gradually, if you tend to stop the treatment.
    • Keep out of reach of children.
  • Recommended tips:
    Storage: Store in the package away from light, in a cool, dry place at room temperature below 25°C.

Migraine is a common neurobiological headache disorder that is caused by increased excitability of the CNS and is often accompanied by nausea, weakness, fatigue and sensitivity to light. Migraine can significantly reduce the quality of life and is classified as a disabling disease by the World Health Organization. Although the exact cause of migraines is unknown, some studies have cited that genetic and environmental factors, chemical imbalances in the brain, and lifestyle may play a role. Due to the debilitating and destructive effects of migraine on the nervous system and general health, there is a vital need for safe and effective medication and appropriate management of the disease. Use of scientifically approved natural and herbal medicines is known as one of the most effective strategies. Migracetum capsules, formulated by Zardband Pharmaceuticals, contain the active ingredients of Tanacetum parthenium plant which is proven by several studies to be effective in treatment of migraine. Among these substances are sesquiterpene lactones and most importantly parthenolide. Parthenolide, a serotonin antagonist, has an important role in pathophysiology of migraine. It may reduce the frequency of migraine attacks by both binding to serotonin receptors and inhibiting migraine inflammatory factors. Migracetum capsules are precisely formulated regarding the active ingredients, medicinal form, and ease of use, to be highly effective in treatment of migraine, and specially reducing the frequency and severity of migraine attacks.

Serotonin, a neurotransmitter in the central nervous system that binds to its receptors, facilitates communication between nerve cells. It could both inhibit and promote migraine pain. Binding of serotonin to some receptors may be involved in triggering migraine and binding to others in preventing it. Due to the role of serotonin in migraine, serotonin receptors are considered as important targets for migraine treatment. The parthenolide content of this capsule, in competition with serotonin, binds to its receptors and prevents the binding of serotonin. As a result, migraine pain could be relieved.1 The NF-kB signaling pathway, an important factor in regulating inflammation, is considered as an effective target for drug intervention. By targeting IkB, parthenolide could inhibit the degradation of both IκB-α and IκB-β and activate NF-κB resulting in reduction of inflammation. Parthenolide also blocks the synthesis of prostaglandins as mediators of inflammation and reduces inflammation.2 Platelet adhesion to leukocytes appears to be higher in migraine patients than healthy individuals due to the release of serotonin from platelets. This may lead to the release of inflammatory cytokines such as IL-1, IL-6, IL-8 and TNF-a resulting in increase of pain and inflammation. Parthenolide, a sesquiterpene lactone, inhibits serotonin release by neutralizing sulfhydryl groups that bind to IkB enzyme. Thus, it has an important role in platelet function and can prevent migraine headaches.