Depression, stress, and their health effects are among the most common life problems today. Mental disorders can seriously affect general health, and that’s why finding safe and effective treatments for them is vital. Standardized natural drugs and supplements are now being widely prescribed to treat mental health issues. Saffromental capsules, formulated by Zardband Pharmaceuticals, contain the active ingredients of Crocus sativus L. plant, which have been found effective in treatment of depression and related mental disorders, by various scientific studies.

Serotonin and Dopamine are the most well-known neurotransmitters that are commonly called happy hormones. Crocin and safranal, two active ingredients of saffron extract, and the most important components of Saffromental capsules, play their role in treatment of depression and associated disorders by regulating the levels of serotonin and dopamine. Furthermore, these active ingredients have a significant effect on bulimia nervosa by regulating dopamine levels. This makes Saffromental an ideal supplement for weight loss, especially besides the regulating effects of crocin on lipid metabolism and the excretion of fats. Depression and metabolism have always been strongly related to low sexual desire and vitality, thus Saffromental capsules, can also be prescribed as an effective supplement to boost vitality and libido.

Serotonin and dopamine are two well-known neurotransmitters with different effects on depression and its associated disorders. Neurotransmitters are actually chemical messengers that carry chemical signals from one neuron to the next target cell. Both dopamine and serotonin are involved in similar processes, but they can operate differently. Serotonin, an inhibitory neurotransmitter, appears to regulate mood and emotions, and improves sleep quality. Dopamine, on the other hand, is an excitatory neurotransmitter, best known for its role in the reward system. It is highly associated with feelings of pleasure and motivation and plays a major role in normal balance and movement, although higher levels of dopamine could trigger impulsive behavior. Deficits in both serotonin and dopamine may lead to symptoms such as depression, sleep deprivation, decreased sex drive, lack of motivation, and concentration difficulties.

Norepinephrine, also known as noradrenaline, is a hormone released into the bloodstream, that mainly functions as a neurotransmitter in the CNS. In the brain, norepinephrine increases arousal, alertness, and attention. It also increases heart rate, stimulates the release of glucose, and increases the blood flow to skeletal muscles. It has been demonstrated that the level of norepinephrine had been low in people with chronic depression, and high in people with hyperactivity disorder and lack of concentration.

The effectiveness of Saffromental capsules is due to the different mechanisms of actions of its two main active substances; crocin and safranal. Crocin, inhibits the reuptake of both dopamine and norepinephrine and plays a key role in balancing the levels of these two neurotransmitters. Safranal, on the other hand, inhibits the serotonin reuptake, and by keeping serotonin at a desired level, plays the main role in the treatment of depression.

The crocin content of Saffromental, also makes it an effective supplement in weight loss plans. One possible mechanism of this effectiveness is that crocin inhibits the activities of pancreatic lipase, resulting in the reduction of fat absorption, and an increase in their excretion.

Crocin also increases adiponectin, which is responsible for glucose metabolism and fatty acids oxidation, and can effectively help losing weight by regulating metabolism. There is also the hormone leptin, which regulates the energy balance in the body by controlling the appetite. Crocin induces weight loss and improves energy balance by regulating leptin levels and consuming the energy stored in adipose tissue.

As mentioned earlier, crocin balances the level of dopamine by inhibiting its reuptake. Due to dopamine role in the reward system, its level is directly related to food-seeking behavior in humans. Peripheral dopamine is also involved in the regulation of sympathetic stress, digestion, and gastrointestinal motility. Overeating due to depression or a symptom known as “bulimia nervosa” is actually caused by a decrease in dopamine levels, stimulating the reward system. Crocin reduces these effects by keeping dopamine levels balanced, and this makes it an ideal supplement for weight loss by overcoming the bulimia nervosa.